Hyaluronic acid (HA) is a natural absorbable glycosaminoglycan, the most abundant essential constituent of the human body, (umbilical cord, eye, synovial fluid, dermis, etc.). It is naturally present in the dermis and is an essential constituent of the structure of the skin giving it hydration, suppleness and tone. It could be compared to a sponge capable of binding to water and retaining it in the deep layers. The role of hyaluronic acid is therefore essential to maintain the 70% water in young skin!
In other parts of the body however its function is to provide viscosity for the fluids necessary for shock-absorption (joint fluids) and for filling cavities (vitreous humour of the eye).
It is a ubiquitous molecule (identical in all species) which is perfectly tolerated by the organism. Over time and depending on each individual, its concentration and quality reduces both in the dermis and in all the other parts of the body where it is found.
Hyaluronic acid can be of animal origin (extracted from cocks’ combs) or be the result of biofermentation (bacterial fermentation). Laboratoires VIVACY use hyaluronic acid produced through biofermentation. In the laboratory it undergoes a slight chemical change (cross-linking method) so that it is more stable and retains its properties longer over time. In fact, when unmodified its lifespan in the human body is only several days!
Hyaluronic acid has been used for more than 20 years in many products throughout the world. Because of its unique rheological properties, biocompatibility, biodegradability, HA has been extensively investigated in drug-delivery applications.
Hyaluronic acid, a natural component of the vitreous humor of the eye, has found many successful applications in ophthalmologic surgery (i.e. corneal transplant surgery, cataract surgery, glaucoma, protection of the corneal endothelium etc.). Furthermore, HA solutions also serve as a viscosity-enhancing component of eye drops and as an adjuvant to eye tissue repair.
Hyaluronic acid plays a vital role in the development of cartilage and the maintance of the sinovial fluid surrounding the joints. Because of its viscoelastic nature and ability to form highly hydrated matrices, HA acts in the joint as a lubricant and shock absorber. Intra-articular injections of HA are used in joints (e.g. knee, hip, finger, etc.) in order to increase the viscosity of the synovial fluid and provide more cushioning support for joints to move freely without pain.
Hyaluronic acid is considered to be a new anti-ageing miracle molecule for skin rejuvenation and soft tissue augmentation (e.g. wrinkle correction, restoring of facial volume and contours).
Hyaluronic acid is used as an ingredient in beauty and skin care products because of its moisturizing and anti-ageing properties.
All hyaluronic acid fillers are cross-linked in order to resist natural degradation and make it last in the skin. The first innovation involved non-animal biphasic HA gels. The second generation had monophasic gels. The third generation is now with STYLAGE® – a non-animal monophasic hyaluronic acid gels multi-cross-linked with an antioxidant mannitol according to the unique IPN-Like Technology or InterPenetrated Cross-linked Networks (a patent filed by Laboratoires VIVACY).
Thanks to the advanced engineering of Laboratoires VIVACY, IPN-Like technology results in a safe, long-lasting product for all types of wrinkles and skin types. It has optimised elasticity for easy modelling and reshaping, even for delicate areas like the nose, temples and hands. At the same time it has a high viscoelasticity for good filling capacity and natural aesthetic results thanks to its smoothing effect.
Compared to the classic cross-linking technique, IPN-Like technology, involves combining, inserting one into another, two monophasic hyaluronic acid networks previously purified and cross-linked which are mechanically independent, so that gel is easy to inject and the increased density of its cross-linking nodes requires less BDDE (cross-linking agent) and makes it longer-lasting*.
* The duration of the treatment is very individual and depends on many factors, such as the patient’s skin type and structure, age, lifestyle, the area treated and the injection technique used by practitioner.
Cross-linking is a process which binds the molecules together by strong covalent chemical bonds, very greatly slowing product breakdown (without cross-linking, the metabolism of the NaHa after intradermal injection takes only several days to several weeks). So the greater the cross-linking of the product, the more compact it is and the longer it lasts. However, it becomes more difficult to inject.
Cross-linking for the STYLAGE® range is performed by a well-known agent (BDDE, or ButaneDiol Diglycidyl Ether, used in the medical field for more than 20 years) in conditions generating ether bonds that are particularly stable in the face of breakdown.
During an intradermal injection, the invasive movement of the needle through the skin’s layers provokes an inflammatory response. Free radicals are then produced that damage cells which puts stress on the skin. During injections, hyaluronic acid will be the first molecules to be attacked by free radicals. Consequently, the filler injected depletes quickly and results cannot be maintained for prolonged period of time.
The addition of mannitol, an antioxidant naturally found in fruits, certain vegetables and plants, within STYLAGE® slows the effects of post-injection radical breakdown. This means that there is an immediate and maintained result because the product is not broken down in the hours following the injection. This reduction in intradermal skin trauma means that less of the hyaluronic filler is lost during treatment.
A clinical follow-up over one year after the first STYLAGE® injection found that the smoothing effect and effectiveness of the treatment observed by both patients and doctors was maintained and very successful ('Retrospective, multicentric, open, non-controlled study on STYLAGE® products. 1 year follow-up'. VIVACY scientific data). The quality of skin was dramatically improved.
As a thermal stabilizer, mannitol also helps maintain the stability and physico-chemical properties of the STYLAGE® gel in the syringe during its storage at room temperature ('STYLAGE® - Mannitol, the Antioxidant of Choice'. VIVACY scientific data).
Sorbitol, like mannitol, is an antioxidant agent that acts as a free radical scavenger. Moreover, it has been safely used in pharmaceuticals, cosmetics and beauty products for a long time due to its powerful moisturizing properties. Complementary to the STYLAGE® range with mannitol, sorbitol has been incorparated into STYLAGE® HydroMax, a dermal filler specifically developed by Laboratoires VIVACY to improve skin hydration and elasticity. As a very hygroscopic antioxidant, it helps skin retain water to conserve moisture and thereby keeps it looking healthy and youthful.
STYLAGE® HydroMax has been successfully used to treat different areas such as the face, neck, décolleté and hands. Its innovative formula offers preventive and curative skin care for both young and mature skin with excellent long-term results.